Cardiovascular Physiology Core

The Cardiovascular Physiology Core is designed to provide cutting edge surgical techniques, in vivo imaging, and physiological measurements (Langendorff, Blood Pressure, and primary cell isolation). We provide intellectual expertise primarily in the area of cardiovascular physiology, collaborate nationally and internationally, both on the development of appropriate models for disease and on the use of established experimental models of disease (e.g. renal, hepatic, vascular,  cardiac, amyloid, sepsis etc) . The  CV Core routinely investigates safety and efficacy of novel therapeutics (genetic or chemical) on small animal models (fish and rodents) and performs expertise on associated work that stems from physiological assessment eg., cell culture/in vitro and ex vivo.  As such, we offer a full service preclinical study management option, and work collaboratively in a cross-disciplinary manner.

A Select list of some of the publications that came out of core collaborations can be found under the Profile: Sudeshna Fisch  in Harvard Catalyst.

To submit or inquire about a service order please visit our Institutional Site and or login to "iLab" -our scheduling interface (if first time, register following link below, its free).

Personnel/Contact Information:


Jane Leopold, MD
Phone: (617) 525-4846
Fax: (617) 525-4830

Associate Director: pending

Alex Loscalzo  (Core Manager/Blood Pressure Specialist)
Phone: (617) 525-4862
Fax: (617) 525-4868

Souen Ngoy (Core Surgeon)
Phone: (617) 525-4866
Fax: (617) 525-4868

Facilities and Equipment:

Location of Core Suite and Ofices: 
77 Avenue Louis Pasteur, New Research Building, Floor 4, Rooms 431 and 435F

Major Equipments:

Vevo3100 by Visual Sonics/Fujifilm, a preclinical ultrasound imaging platform

Visitech Blood Pressure Systems

MACS Cell Isolation System

Getting started:

To schedule a service please visit our iLab Site.

For further information, contact : Alex Loscalzo (

Our fee schedule (direct cost) is as follows:


Services Internal External NonProfit  External Industry
Ultrasound: Self Service $             115.00   $             165.60   $             182.85 
Ultrasound: Assisted/Training $             175.00   $             252.00   $             278.25 
Surgery: MI/IR/AC/deAC/PAC $             150.00   $             216.00   $             238.50 
Surgery: Other $             170.00   $             244.80   $             270.30 
Blood Pressure Measurement: Self Service $               75.00   $             108.00   $             119.25 
Blood Pressure Measurement: Assist/Train $             100.00   $             144.00   $             159.00 
Neonatal Cardiomyocyte Isolation $             250.00   $             360.00   $             397.50 
Adult Cardiomyocyte Isolation $             250.00   $             360.00   $             397.50 
Langendorff $             160.00   $             230.40   $             254.40 
PV Loop $             160.00   $             230.40   $             254.40 
Data Analysis: Self Service $               50.00   $               72.00   $               79.50 
Data Analysis: Assisted/Training $             150.00   $             216.00   $             238.50 
Misc: Animal Monitoring (/15min) $               50.00   $               72.00   $               79.50 
Misc: Consulting (/15min) $               50.00   $               72.00   $               79.50 

Cancellation Policy:

Requests for cancellation and changes, including those related to the number of animals must be placed exclusively through the Core iLab portal. Users can make adjustments directly on iLab up to seven days prior to the expected service date. Should there be a change in the number of animals seven days or less to the expected service date, the User may be held responsible for the cost of animal purchase, housing and for any preparation related to the requested service, including but not limited to the purchase of reagents and other materials.  

No fee will be charged if service could not be rendered due to core cancellations on account of unforeseen circumstances including but not limited to inspections and equipment malfunction and due to “Acts of God” circumstances.  Should circumstances warrant the cancellation of a service or services, the Core will make its best effort to inform user(s) as soon as possible and will strive to inform the user within 24 hours. For further clarification, please reach out to Alex Loscalzo.