We are a large animal research facility that focuses on novel therapies for human disease. We work with investigators from multiple scientific specialties and provide assistance with experimental design, protocol submission, surgical procedures, and data analysis.
The facility houses a fully functional operating room and fluoroscopy suite. Major equipment includes: GE flat panel fluoroscopy system with hemodynamic and electrocardiographic monitoring, cardiovascular electrophysiology equipment for mapping and ablation, transthoracic echocardiography, intracardiac echocardiography, and optical coherence tomography. We have access to the adjacent BWH research MRI facility for projects with advanced imaging needs.
The PMB Microscopy Core in the Simches Research Center provides a full range of light and electron microscopy (EM) services to the MGH community. We specialize in immunogold labeling at the EM level in cells, tissues, and lower organisms (flies, worms). We perform EM analysis of exosomes and cellular fractions (mitochondria, lysosomes, autophagosomes). Two powerful confocal platforms allow live cell imaging (Nikon A1R) and high resolution imaging of samples (Zeiss LSM800 with Airyscan), in addition to tissue sectioning, staining, conventional fluorescence imaging, and laser cut microdissection. We provide user training and assisted support as needed. Our experienced technologists and PIs give detailed project support. We have contributed to hundreds of publications and successful grant applications over the years.
(Left to right) Senior Core EM Technologist Diane Capen at the JEOL 1011 electron microscope Drs. Brown (Director), Breton (co-Director) and Bouley who are PIs in the PMB, providing support to Core users.
Research core facilities at Partners HealthCare bring state-of-the-art instrumentation, methodologies and expertise crucial to the promotion of research on our campuses and beyond. There are over eighty cores, across the Partners Hospitals, established to share their expertise, facilities and equipment in order to efficiently use resources, promote collaboration, and further enhance the competitiveness of Partners investigators to secure research funding.
The Partners Core Management System provides Core users with one stop shopping of all Partners cores on the system. Core users have the ability to create user accounts to manage funding, request services and check the status of requests at their own convenience. The system is in the early stages of implementation so be sure to check back regularly to see what Cores have been added.
To download a Quick Guide to Using the Partners Core Management System click here.
RESEARCH CORE FACILITIES TEAM
Ramesh earned his PhD in Biochemistry from U. Mass Medical School and joined the Division of Immunology, Boston Children’s Hospital (BCH) as Post-doctoral fellow. He remained with the Division of Immunology, BCH for over two decades as a PI and as the Director of Laboratory Research for seven years. His main research focus was on the molecular basis of Primary Immune Deficiency diseases with emphasis on the role of actin cytoskeleton in T cell function. Ramesh has published over 60 original papers, book chapters and reviews. He left research to join Research Administration at BCH and moved to Partners Research Core Facilities Office in December 2014.
Yovani Edwards Is a Senior Financial Analyst at the Research Core Facilities Office. She has been with the Office since 2011 and believes that the past five years as a Financial Analyst at Partners Healthcare has been a great learning experience and a wonderful way to help the research community. She on the board of the Directors (Treasurer) for Community Alliance. Yovani graduated with a Master’s degree in Finance from Bentley University. In her free time, she enjoys reading and watching Documentaries.
Jessica is a Senior specialist at the Research Core Facilities Office. Jessica is from West Warwick, Rhode Island. She graduated from the University of Connecticut with a major in Biomedical Engineering. After her graduation she joined Partners Healthcare as part of their Research Management cohort training program and at the completion she was appointed as a specialist with Research Cores Facilities Office. She is a candidate at Boston University for a Master’s in Business Administration with a focus on the Healthcare System.