Research Cores

MGB Personalized Medicine Biobank Genomics Core

At Your Service

At Mass General Brigham Personalized Medicine Biobank Genomics Core (BGC), we offer genotyping and next generation sequencing services to support research studies. With over a decade of experience and a proven track record of helping MGB investigators achieve their research aims, our goal is to make sequencing/genotyping technologies accessible to the research community.  

Our services are listed below, please contact us for additional information on any of our services, or for pricing. We also provide support documentation (letter of support, workflow description, quotes) to support grant applications.

Accounts and Ordering

All projects are managed through our internal Laboratory Information Management System (StarLIMS), with orders for services submitted via RCMS (Core Management System).

Submit an Order/Service Request

Please submit a service request prior to submitting samples. To do this, you must first set up a RCMS account. You also must have a valid MGB IRB # and a Grant number or PO number.  Detailed instructions can be found in this user guide.   

Sample Submission Guidelines

*  Samples cannot be delivered until an order has been submitted through RCMS https://researchcores.partners.org/cores

*  Please contact us 24 hours in advance of delivering any samples to the lab

PHS PPM Core – PPMCore@partners.org

PHS PPM Central Biobank – PPMCentralBiobank@partners.org

*  Samples can be delivered to Thorn Building – Brigham and Women’s Hospital, Personalized Medicine – Biobank Genomics Core (TH1423), 20 Shattuck Street, Boston MA 02115

*  Samples are accepted Monday-Friday from 9am-12pm and 1pm-3pm

*  All samples are subject to QC analysis upon arrival

*  After processing, any residual sample material is held in our freezer for 30 days after processing, after 30 days samples are subject to discard without further notice

*  Any data that is generated on any of the platforms below will be maintained for 90 days after data delivery and will then be deleted without further notice

*  Sample IDs should be less than 13 characters and may only be composed of alphanumeric characters and/or hyphens (-).  Please do not use underscores (_) or periods (.)

*  Accepted container types:

< 24 samples: VWR free-standing RNase/DNase free 0.5ml tubes (89004-286)

   > 24 samples: Fisher RNase/DNase free plates (AB-0800) Samples should be plated column wise A01, B01, C01 etc.

Sample Requirements

*RNA samples: If RNA is extracted using TRIZOL or other organic reagents, the final clean-up step must be performed using an RNeasy column cleanup or other similar method. RNA samples should also be prepared using an in-solution DNAse treatment.  We have found on-column DNase digestion has not been suitable to eliminate all DNA. Note: Incoming total RNA tubes and plates should also include a QC aliquot.  The QC aliquot should contain 5 ul sample.

Where is MGB Personalized Medicine Biobank Genomics Core located?

Mass General Brigham Personalized Medicine - Biobank Genomics Core
20 Shattuck Street
Thorn Building - RM1423
Boston MA 02115

How do I receive my data?

You will be contacted when data is available. Depending on size, data can be shipped to you on an external hard drive. We can also coordinate other delivery mechanisms. Data will remain available from MGB Personalized Medicine for 3 months.

Contact MGB PM Biobank Genomics Core

For Illumina Next-Gen Sequencing and Genotyping quotes and customer inquiries, please email PPMCore@partners.org

For DNA/RNA Extraction and sample handling service quotes and customer inquiries, please email PPMCENTRALBIOBANK@partners.org

For help placing an order or other IT-related inquiries, please email PMBGCIT@mgb.org