The Advanced Tissue Resource Center in the Department of Neurology at Massachusetts General Hospital serves as a molecular and anatomic neuropathology resource for the Boston neuroscience community. Our services incorporate advanced micro-molecular profiling technologies into studies of human neurodegenerative and psychiatric diseases.
The Antibody Core Facility provides commonly used monoclonal antibodies to the BWH research community. The antibodies are available in convenient 500µg aliquots at a cost substantially lower than that of commercial vendors.
Array Tomography is a light microscopic method of analysis that allows increased structural detail to be achieved at the light microscope level such as that associated with individual synapses.
The core generates clinically approved compounds for PET scans, research tracers for human use, preclinical tracers, novel tracers as requested by investigators and offer small animal imaging services such as microPET/CT and microSPECT.
The Core will provide statistical services that include consultation for grant preparation, data management, data analysis, electronic data capture, and the management and coordination of multi-center clinical trials to Clinical and Laboratory Investigators.
Bone Cells Core facility provides specific-type bone cells isolated directly from wild type and/or genetically modified animals. The core provides tools, such as vectors, plasmid and lentiviruses, to manipulate these cells. Finally, the Core offers in vitro fluid flow and simulated microgravity experiment services.
The core provides high quality, reproducible measures of bone mineral density (BMD) and body composition by dual energy x-ray absorptiometry (DXA).
The core provides state-of-the-art high-quality research assays, especially useful for clinical research, to the investigators at reduced costs. The list of assays offered by the core may found in the core website.
The facility is equipped with, Olympus FV1200 confocal microscope (without multi-photon capability) consisting of an Argon 458/477/488/514 nm laser, a Green HeNE 543 nm, a Red HeNe 633 nm laser, and a Coherent ULTRA near infrared tunable Titanium Sapphire laser (690 - 1040 nm). The systems allow a range of experiments with fixed or live samples with time lapse function available on all systems making it possible to perform experiments over time courses in 5 different channels. Investigators with expertise in mammalian cells, yeast cells, Drosophila and Zebra fish embryos and ovaries, bacteria, and other tissues are available to help the users.
Provides zebra fish husbandry and help with procedures.
Provides small animal husbandry and help with procedures.
This Core provides sorting services for the isolation of cells within a biosafety cabinet for BL2 level sterile sorting.
The Single Cell Genomics Core offers researchers an integrated pipeline to perform successful single cell transcriptomic analyses, including droplet-based single cell transcriptome library preparation, sequencing, and bioinformatic analyses through the core, along with technical expertise on tissue processing, sample preparation, and cell isolation.
Provides access to over 2 million IRB approved frozen biosamples from Nurses Health study, Physicians Health study and Health Professionals follow-up study.
The Center for Advanced Molecular Diagnostics (CAMD) is a CLIA-certified Clinical Molecular Diagnostics Laboratory. Our mission is to provide high quality innovative molecular genetic diagnostic services to support the patient care missions of clinicians and clinical researchers.
The Core provides cell sorting and flow cytometry analysis services to the research community at the Brigham and WomenŠ—Ès Hospital (BWH) and the Longwood Medical area.
The Cardiovascular Physiology Core provides cutting edge surgical techniques and physiologic measurements, as well as intellectual expertise in cardiovascular physiology to the Partners research community.
offers access to Nikon A1 laser scanning confocal microscope with state of the art imaging facility with resonant scanning and spectral imaging capabilities.
The core offers three lines of service to investigators (a) DNA sequencing (b) DNA synthesis and (c) automation of various assays for research purposes.
This core is a resource center that optimizes and utilizes all donor organs to provide cells, tissues and organs for research and therapeutic uses.
This core provides research investigators with experienced research staff to assist in the start-up, implementation, and close out of clinical research studies. Services provided include Biostatistics, Nursing and Nutrition, Outpatient services and Research coordination.
Provides small animal husbandry and help with procedures.
The Core will provide services to measure levels of a variety of signaling molecules, such as cAMP, IP3, iCa++, and P-ERK-1/2, in cell culture or tissue systems.
The goal of the core is to serve the computing needs of the epidemiology community of the Channing Laboratory and beyond. In that vein, the Core provides fast access to our server for data management and analysis and storage for large data sets especially for whole genome genetic studies.
The Chronobiology Core provides a central resource for trained personnel specialized in Chronobiology procedures, available to Investigators on an hourly basis.
The Circulating Tumor Cell (CTC) core provides users with FDA-approved method for the isolation and quantitation of circulating tumor cells from peripheral blood samples of patients with metastatic cancers.
Provides clinical samples or consented patient samples to research purposes.
provides access to Nikon A1 automated high speed image capturing microscope.
The core offers: *The Olympus Multiphoton FVMPRE-RS Microscopy System for cutting-edge research imaging *The Leica SP8 Laser Scanning Microscope *The Nikon
The program offers high resolutions magnetic resonance (MR), positron emission tomography (PET-CT), signal photon emission computed tomography (SPECT-CT), computed tomography (CT), Fluorescence mediated tomography (FMT-CT/MRI), bioluminescence (BLI), various fluorescence imaging technologies and intravital confocal and multiphoton microscopy. The integrated program also provides several mouse holding facilities for serial surgery anesthesia, veterinary care and injection of imaging agents. Imaging recontruction, 3D display fusion, quantitative imaging analysis and server access area also available.
The core provides DNA extraction from samples provided by the investigators primarily to Heart Center investigators for a low cost fee. However, the core has the capacity to offer services to other investigators, if requested.
The mission of the Cardiovascular, Diabetes, and Metabolic Disorders (CVDM) Research Center is to foster and stimulate collaborative research and technological innovation that will lead to groundbreaking and effective approaches for the diagnosis, prevention and treatment of cardiovascular diseases, diabetes, and obesity. The core is a repository of human myocardial, vascular, and stromal tissues.
The core offers conventional karyotyping and fluorescent in situ hybridization of both human and rodent samples and array based comparative genome hybridization.
The core provides investigators with the necessary expertise and resources to design and undertake pharmacokinetic studies in the context of phase I and phase II clinical trials, and preclinical investigations.
The CoreÎ¾provides flexible, high-quality, high-throughput single nucleotide polymorphisms (SNP) genotyping to the research community. Its mission is to provide services to researchers conducting molecular analyses of germline and somatic DNA collected as part of a wide range of investigations into the molecular epidemiology of cancer, including Genome Wide Association Studies (GWAS).
The core laboratory provides objective anatomic and functional imaging measurements, which enhances the efficiency and quality of clinical trials.
The mission of the Clinical Research Program Study Coordinators Core (CRP SCC) is to provide infrastructure support for clinical research investigators at the MGH.
This core provides frozen fecal material for transplantation for treatment of recurrent colitis, especially C. difficile colitis.
This provides functional MRI services and is very effective in studying brain hemodynamics.
This core provides access to cutting edge genomics technologies and computational biology resources for Partners investigators.
The core offers the services of one of only 4 Xtreme CT scanners currently in the US. High resolution peripheral computerized tomography (HR-pQCT; Xtreme CT; Scanco Medical AG, Bassendorf, Switzerland) is a new technology that allows for 3 dimensional reconstruction of bone microarchitecture and image separation of cortical and trabecular bone. This technology is especially useful in women's health studies.
The core offers histopathological studies including examination of tumor specimen, neurohistopathology, immunohistochemical studies on human, non-human primate and rodents calibrated primarily for MGH users. A sister facility caters BWH users.
The Core provides an advanced level of sorting and analysis services to its investigators.
This core investigates HIV pathogenesis and evaluates preventive and therapeutic interventions, as well as immuno-oncological frameworks. This endeavor is done by the creation of an improved humanized mouse model capable of generating HIV-specific human cellular and humoral immune responses.
The HSDRC provides access to fresh and banked human skin specimens and cutting edge techniques for analysis of human skin including CyTOF mass cytometry, multiplex immunofluorescence microscopy, T cell receptor sequencing, and NanoString gene expression analysis.
The ID Retrovirology Core processes samples from HIV- and HCV-infected patients participating in clinical research studies. Services include plasma and serum separation, peripheral blood Cncermononuclear cell isolation and cryopreservation, and preparation of cell pellets.
Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis in adults and children.
The Core isolates and distributes high quality human, non-human primate, porcine and rodent islets for basic scientific research studies.
This research resource core will organize, label, maintain, and distribute rare-earth metal labeled antibodies for CyTOF mass cytometry.
The core provides breeding and husbandry of gnotobiotic mice and assists investigators with analyses regarding effects of metabolic, immunologic and other physiologic effects following host colonization commensal and/or pathogenic microbes. The core also provides consults on microbiome and bioinformatics.
MIC offers the research community a wide range of magnetic resonance and near infrared imaging services including all types of major structural, functional, neurochemical and electrophysiological techniques to integrate with other research and clinical programs both at McLean Hospital and with research groups in the Boston area. Services include consultation, protocol development, data storage and analysis.
The core offers Comprehensive Laboratory Animal Monitoring System (CLAMS) studies to noninvasively measure a variety of calorimetric and metabolic data in mice. The calorimetric data recorded by the system includes oxygen consumption and carbon dioxide production values, from which both heat values and respiratory exchange ratios (RER) can be calculated.
The Musculoskeletal Imaging Research Core (MIRC) offers specialized imaging techniques including quantitative computed tomography (QCT),magnetic resonance (MR) spectroscopy of muscle and high-resolution soft tissue MR imaging.
The core provides information management and analysis needs of the MGH/Partners/Harvard research community as well as non-profit organizations and industry.
The core has a Zeiss LSM710 Inverted Confocal Microscope with floating air table, and CO2 and a heated stage insert for live-cell imaging
The DF/HCC Specialized Histopathology Services Core in MGH provides high-quality, timely, state-of-the-art technical and professional pathology services to investigators. The core has expertise working with human tissues as well as a variety of experimental models (including rodents, fish, pigs and monkeys). The Core performs routine histology and special histochemical stains and also assists in experimental design and the development, application, and interpretation of biomarkers. Services include: • Tissue trimming, processing and embedding, • Cutting and staining of paraffin-embedded sections • Cutting and staining of frozen OCT sections • Special stains • Immunohistochemistry manual - optimization and staining, for routine and novel markers • Immunohistochemistry automated - optimization and staining, for routine and novel markers • Eye pathology services (human and mouse) • Dual staining (immunohistochemistry)
Offers comprehensive positron emission tomography (PET) services. The core has state of the art facility for PET/CT scans including automated radiochemical synthesis facility, large bore PET scanner, Siemens SPECT system and planar gamma cameras, neuro PET/CT high sensitivity brain scanner, and VISTA small animal micro PET/CT scanner.
This core provides flexible morphometric measurement service, especially neuroanatomic morphometry, to meet the needs of the clinical community. It operates in conjunction with Martinos center for Imaging.
The Core provides access to the most sophisticated flow cytometers and mass cytometer (Helios) presently available for cell sorting, flow cytometric analysis and single-cell mass cytometric analysis respectively.
The core provides Transmission electron microcopy and confocal microscopy services.
The Mission-Driven Service Core provides custom services for investigators in the Partners community to carry out genetic studies in human disease.
The core offers a library of services to study protein-protein interaction at the cellular and molecular level. The technology offered include fluorescence lifetime imaging microscopy (FLIM), Forster resonance energy transfer (FRET) studies, high quality epifluorescence, time lapse microscopy, data analysis and storage facilities.
This core custom generates cDNA clones and shRNA lentiviral constructs for investigators.
The Core will provide investigators with consultation and analytic services, and will design, build, and test functionality of approved projects to fully leverage the Epic eCare system for research purposes.
The core serves as the central IRB for multi-site research conducted by NIH-funded networks.
The Laboratory for Molecular Medicine (LMM) is a CLIA-certified molecular diagnostic laboratory, operated by Partners HealthCare Personalized Medicine.Ê
The core provides the necessary expertise and services to analyze variations in individual genome that translates into medical decisions, practices, interventions tailored to the individual patient (or a small cohort) based on their predicted response or risk of disease.
The ERIS Research Computing Core provides consulting and technology services to researchers and their project teams at competitive hourly rates. The Core collaborates with users on finding efficient solutions using technology for the unique needs of research environments
The core offers synthesis and purification of custom peptides. It also offers protein sequencing (automated Edman degradation) and protein mass spectrometry services.
The Integrated Analytics core has been established by the division of Pharmacoepidemiology and Pharmacoeconomics to allocate computer programmer effort and closely related costs to federal and non-federal projects. The division of Pharmacoepidemiology and Pharmacoeconomics specializes in analyzing massive data sets related to prescription data use.
The core will serve as a resource for studies in cardiovascular medicine using NMR. The core provides tools to define the cardiac energetics (using 31P NMR), metabolism (using 13C NMR) and hemodynamic function (the isovolumic contractile performance) of isolated hearts.
The core offers access to state of the art optical, fluorescence and electron microscopy (including immunogold labeling), and image analysis software. Major equipment includes a JEOL 1011 electron microscope, Nikon A1R and Zeiss LSM800 with Airyscan confocal microscope platforms, Nikon 90i and 80i conventional fluorescence microscopes, Leica cryostats and ultramicrotomes, and an MMI laser cut micro dissection system.
Supports BSL-3 level experimental procedures by investigators at Partners Healthcare and Boston community. The core aims to enable external users to access the unique benefits of a BSL-3 facility, and to provide comprehensive services in support of this goal.
The Ragon Institute offers flow cytometry, fluorescence-activated cell sorting, and advanced microscopy and image analysis services.
Provides imaging service for research purposes.
The core provides high quality pharmaceutical services to the research community and supports growth of McLean HospitalŠ—Ès clinical research portfolio.
The Sample Processing Laboratory (SPL) is a centralized core facility for processing research samples obtained from patients enrolled in clinical trials of anticancer chemotherapeutic agents at the MGH Cancer Center (MGHCC), for short-term storage and shipment to designated laboratories.
The core houses an Agilent Seahorse XFe24 instrument and provides functional metabolic studies on live tissues and cells.
The Sleep & EEG Core within the Division of Sleep Medicine (DSM) provides an integrated infrastructure and knowledge base in support of research projects that use polysomnography (PSG), quantitative EEG analysis and related methodologies
The overall goals of the core were to create a representative sample of people with MS living in the US; develop instruments and methods for collecting data to address a wide range of epidemiological, health services, basic science, and psychosocial research questions; construct an analytic database; and implement longitudinal data collection and management.
The Core provides cell sorting and flow cytometry analysis services to the research community at the Brigham and Women's Hospital (BWH) and the Longwood Medical area.
The aims to establish the impact of genetic variation on the function of the human body. It is also a resource that provides a source of fresh and stored biological samples from healthy human subjects, as well as an electronic atlas that references the expression of genes to the variation found within those genes for research use.
Centralized repository of patient and normal tissue and blood samples.
The Translational Discovery Laboratory (Core) provides state of the art facility and trained staff for large animal experimentation with an emphasis on percutaneous cardiovascular technologies.
The core will offer advice on strategies for cloning, provide relevant plasmids and help packaging lentivirus based vectors, retrovirus and Aden associated virus (AAV). Custom packaging and tittering services are also offered.