Metabolic Imaging Core

The MGH Metabolic Imaging Core (MMIC) offers specialized imaging techniques including high-resolution soft tissue magnetic resonance imagining (MRI), magnetic resonance spectroscopy (MRS), quantitative computed tomography (QCT), and ultrasound for human research studies.

Personnel/Contact Information:

Director: Borek Foldyna, M.D., Ph.D
Email: bfoldyna@mgh.harvard.edu

Associate Director: Eva Ratai, Ph.D
Email: eratai@mgh.harvard.edu

Other Staff:

Core Manager: Marilyn Galdámez
Phone: (617) 643-7465
Email: megaldamez@mgh.harvard.edu 

Senior Clinical Research Coordinator: Ivanna Zorgno
Email: izorgno@mgh.harvard.edu 

Facilities and Equipment:

Location: Mass General Imaging - Boston, 55 Fruit Street, Yawkey 6E, Boston, MA 02114.

Major Equipment: The MMIC has access to state-of-the-art technology in diagnostic imaging available at the Massachusetts General Hospital main campus, MGH Yawkey Center for Outpatient Care, and Martino's Center for Biomedical Imaging. Available equipment for research imaging includes:

  • 3T Siemens Vida
  • 1.5T Siemens Avanto
  • 3T Siemens Prisma
  • 3T General Electric Discovery
  • 1.5T General Electric Signa
  • Siemens NAEOTOM Alpha
  • General Electric Revolution CT 256-slice
  • General Electric LOGIQ E10 Series Ultrasound

Core Services:

These are the most common services we provide our users, which can be adapted to meet the needs of various studies. (Custom imaging protocols are available upon request.)

Study Start-Up:

  • Support Investigators with study design and imaging methods for human research studies
  • Facilitate imaging site qualification for industry sponsored Clinical Trials
  • Training study staff in MGB Radiology Research Scheduling Good Practices

MRI and MRS:

  • 1H-MRS of muscle, liver, marrow and adipose tissue with analyses for lipid profiling
  • Magnetic resonance elastography (MRE) for assessment of liver fibrosis
  • Quantification of areal and volumetric visceral and subcutaneous adipose tissue, cross-sectional muscle area
  • Liver MRI for assessment of steatosis and fibrosis (using Perspectum Multiscan protocol)
  • Brain MRI and MRS*
  • Functional MRI*

* Services offered through Martino's Center for Biomedical Imaging

CT:

  • QCT - helical using single- or dual-energy CT for volumetric acquisition of bone mineral density
  • QCT single-slice for quantification of visceral and subcutaneous adipose tissue, cross-sectional muscle area
  • CT analysis for body composition performed with deep learning algorithm (ideal for medium or large-scale studies or datasets requiring short-term execution
  • Photon-Countung CT

Ultrasound:

  • Quantitative ultrasound 
  • Shear wave elastography (SWE) for assessment of liver fibrosis and steatosis

Positron emission tomography (PET) :

  • PET**
  • PET/CT**
  • PET/MRI**

** Services offered through MGH Gordon PET Core.

Other Services:

  • Scheduling radiology research imaging procedures
  • Imaging analysis, including quantitative interpretation of imaging data
  • Data transfers to external institutions
  • Workshops in imaging techniques used in metabolic investigation

Getting Started:

For further information please fill out our Service Request Form or contact us at MMIC@mgh.harvard.edu.

Departmental Web Link:
https://bostonareanorc.org/center-cores/metabolic-imaging-core/