- MGH Gordon PET Core
The MGH PET Core is cGMP/FDA registered PET drug manufacturer that operates at cost to provide investigators with required personnel, equipment and services to design and conduct research studies using positron emission tomography.
Main services include:
- Synthesis of radiotracers and radiopharmaceuticals
- PET and SPECT animal and human imaging
- Experimental design and pharmacokinetic modeling
- Validation and regulatory submission of compound for human use
F-18
FDG* (tumour metabolism/hypometabolism)
Florbetaben** (amyloid imaging)
Flutemetamol** (amyloid imaging)
Florbetapir** (amyloid imaging)
Fluciclovine** (tumor metabolism/prostate cancer imaging)
Sodium Fluoride** (bone imaging)
FES (estrogen receptor)†
Flortaucipir [T807] (tau protein)†
FPEB (mGlur5)‡
BFPET (myocardial perfusion) †
GE180 (TSPO/PBR)†
FLT (cellular proliferation)†
FET (amino acid uptake) †
THK 5351/GE-216 (tau protein)†
FMISO (hypoxia)†
MK-6240 (tau protein) †
GE179 (NMDA receptor)‡
C-11
PiB
Altropane
Raclopride
Methionine
CO
Rolipram
P943
PBR-28
(S,S)-[11C]Methylreboxetine
Nociceptive
N-13
Ammonia*
N2 in Saline (lung perfusion imaging) ‡
Ga-68
DOTATATE** (neuroendocrine tumor imaging)
O-15
C15O2 (blood flow imaging) ‡
*FDA approved, MGH PET Center holds FDA marketing authorization
**FDA approved, available through local commercial nuclear pharmacies
†Active IND held by MGH Gordon PET Core
‡Available under Radioactive Drug Research Committee (RDRC) oversight
| Services | Internal User Fee for Non-Profit and Federal Sponsored Research (Direct Cost) | External User Fee for Non-Profit and Federal Sponsored Research (inclusive of institutional indirect cost) | External & Internal User Fee for Industry Sponsored Research |
| 13N Ammonia | $ 4,060.00 | $ 5,846.00 | Contact us for rate |
| 13N2 PET GMP Production + Imaging | $ 2,900.00 | $ 4,176.00 | Contact us for rate |
| 13N2 PET Production + Imaging | $ 1,400.00 | $ 2,016.00 | Contact us for rate |
| 13 NH3 Cardiac Blood Flow | $ 3,750.00 | $ 5,400.00 | Contact us for rate |
| 18F FDG + Imaging | $ 2,450.00 | $ 3,528.00 | Contact us for rate |
| Other PET GMP Production + Imaging (includes: 11C compounds and 18F compounds; excludes: 18F FDG, 13NH3, 13N2 and 13N Ammonia) | $ 3,500.00 | $ 5,040.00 | Contact us for rate |
| Other PET Production + Imaging (includes: 11C compounds and 18F compounds; excludes: 18F FDG, 13NH3, 13N2 and 13N Ammonia) | $ 2,600.00 | $ 3,744.00 | Contact us for rate |
| PET Imaging Only (no dose, up to two hours) | $ 2,350.00 | $ 3,384.00 | Contact us for rate |
| Additional Imaging Time (per hour) | $ 715.00 | $ 1,029.00 | Contact us for rate |
| Phantom Imaging | $ 1,800.00 | $ 2,592.00 | Contact us for rate |
| PET Compound Dose (No Imaging) | $ 1,750.00 | $ 2,520.00 | Contact us for rate |
| Cyclotron Beam Time Isotope Production (per hour) | $ 1,100.00 | $ 1,584.00 | Contact us for rate |
| Small Animal PET/CT Imaging Only | $ 650.00 | $ 936.00 | Contact us for rate |
| Small Animal Imaging Additional Imaging Hour | $ 300.00 | $ 432.00 | Contact us for rate |
| Blood Processing | $ 1,400.00 | $ 2,016.00 | Contact us for rate |
| Consent Charge | $ 150.00 | $ 216.00 | Contact us for rate |
| CT | $ 1,200.00 | $ 1,728.00 | Contact us for rate |
| IRB Renewal | $ 3,800.00 | $ 5,472.00 | Contact us for rate |
| Kinetic Modeling | $ 1,250.00 | $ 1,800.00 | Contact us for rate |
| Radionuclidic Purity Testing | $ 460.00 | $ 662.40 | Contact us for rate |
| Regulatory Submission | $ 12,000.00 | $ 17,280.00 | Contact us for rate |
| SPECT | $ 2,200.00 | $ 3,168.00 | Contact us for rate |
| SPECT-CT | $ 2,800.00 | $ 4,032.00 | Contact us for rate |
| Start-up Fee | $ 8,000.00 | $ 11,520.00 | Contact us for rate |
| Technician Training / Site Qualification (per hour) | $ 500.00 | $ 720.00 | Contact us for rate |
| Validation of Radiotracer for Animal Use | $ 18,000.00 | $ 25,920.00 | Contact us for rate |
| Validation of Radiotracer for Human and NHP Use | $ 30,000.00 | $ 43,200.00 | Contact us for rate |
| 18F FDG Dose (No Imaging) | $ 200.00 | $ 288.00 | Contact us for rate |
| GA68 PSMA 11 Production + Imaging | $ 7,725.00 | $ 11,124.00 | Contact us for rate |
| GA68 Chloride Production | $ 2,025.00 | $ 2,916.00 | Contact us for rate |
| IRB Protocol Review | $ 2,100.00 | $ 3,024.00 | Contact us for rate |
| Reprocessing / Data Access | $ 225.00 | $ 324.00 | Contact us for rate |
| Optical Imaging (Dual Channel NIR Imaging System) | $ 200.00 | $ 288.00 | Contact us for rate |
| Optical Imaging (NIR-II Imaging System) | $ 250.00 | $ 360.00 | Contact us for rate |
| Optical Imaging (Trifoil InSyte) | $ 300.00 | $ 432.00 | Contact us for rate |
| Optical Imaging (Cytation5) | $ 150.00 | $ 216.00 | Contact us for rate |
| Optical Imaging (JuLi Stage w/ Cell Incubation) | $ 200.00 | $ 288.00 | Contact us for rate |
| Conjugation Service | $ 500.00 | $ 720.00 | Contact us for rate |
Late Cancellation Policy
A PET study that is cancelled or rescheduled within 48 business hours of the original imaging session may incur a fee up to the cost of the cancelled imaging session. A radiotracer production that is not cancelled 48 business hours prior to the production day may incur a fee up to the cost of the produced dose.
Effective 2/9/22: cancellations due to COVID-19 will no longer be exempt from the late cancellation policy.
Late cancellations due to an act of God are not subject to the general cancellation policy. Since our facility operates at cost, please notify Nicole DaSilva at NEDASILVA@mgh.harvard.edu as soon as possible to allow us to make other arrangements.
Overhead Policy
An investigator using a Mass General Brigham fund is considered an internal user and is subject to the overhead rate applied by their institution. The internal user fee is calculated based on the direct costs of providing each service. The external user fee comprises a direct fee negotiated with the PET Core plus an overhead component. The overhead rate set by Mass General Brigham is 44% for external academic users and 59% for external industry users.
Uncompleted Studies
The PET Core commits its best efforts to successfully complete scheduled studies. However, given the very nature of many PET studies that rely on manufacturing of radiopharmaceuticals and in vivo imaging, the Core cannot be held responsible for costs associated with incomplete studies due to equipment failure or circumstances outside of our control.
Acknowledgement of Federal Funding
Measurement of radioactivity in blood and tissue samples uses state-of-the- art equipment acquired through the support of the NIH shared instrumentation grant S10OD018035. Users of our blood sampling and kinetic modeling services are encouraged to acknowledge the grant in their publications and to report it back to us.
The grant details are:
- Project Number: S10OD018035
- Title: Gamma Counter and Continuous Blood Sampler for Quantitative PET Imaging,
- PIs: Georges El Fakhri, Marc Normandin
MGH Main Campus, Boston, MA: Edwards Basement (cyclotron, radiochemistry, and human and large animal imaging)
MGH Navy Yard Campus, Charlestown, 149 13th Street, Charlestown, MA (small animal imaging)
- GE Discovery PET/CT
- Automated Radiochemical Synthesis systems
- E.cam (Siemens) SPECT Systems and Planar Gamma Cameras
- Exact HR+ Large Bore PET Scanner
- NeuroPET/CT dedicated high sensitivity brain scanner
- PC4096 Large Bore PET Scanner
- Siemens PET/CT Scanner
- Siemens Symbia SPECT/CT
- VISTA small animal micro PET/CT
- Tri-modality MicroPET-SPECT-CT
- Perkin Elmer Wizard2 2480 gamma counter
- Perkin Elmer Wizard 3860 gamma counter
- Swisstrace Twilite II continuous blood counter
