Center for Skeletal Research Cores - Histology, Bone Cells, Cell Signaling Assays, and Imaging
The Core will provide services to measure levels of a variety of signaling molecules, such as cAMP, IP3, iCa++, and P-ERK-1/2, in cell culture or tissue systems.
The Core's mission was to facilitate the identification of discarded human tissue for research. Pathology reports were extracted from hospital databases, de-identified and loaded into network to allow aggregated results to be rapidly obtained through a peer-to-peer network.
The core offers histopathological studies including examination of tumor specimen, neurohistopathology, immunohistochemical studies on human, non-human primate and rodents calibrated primarily for MGH users. A sister facility caters BWH users.
The DF/HCC Specialized Histopathology Services Core in MGH provides high-quality, timely, state-of-the-art technical and professional pathology services to investigators. The core has expertise working with human tissues as well as a variety of experimental models (including rodents, fish, pigs and monkeys). The Core performs routine histology and special histochemical stains and also assists in experimental design and the development, application, and interpretation of biomarkers. Services include: • Tissue trimming, processing and embedding, • Cutting and staining of paraffin-embedded sections • Cutting and staining of frozen OCT sections • Special stains • Immunohistochemistry manual - optimization and staining, for routine and novel markers • Immunohistochemistry automated - optimization and staining, for routine and novel markers • Eye pathology services (human and mouse) • Dual staining (immunohistochemistry)