Research Cores

The GTVC offers production of high titer, high-quality, research-grade recombinant adeno-associated viruses (rAAV) for in vitro and in vivo applications. Make a customized rAAV vector order or choose from our inventory. rAAV vector titers are determined by ddPCR, purity analysed by SDS-PAGE, both of which are included in the service. Endotoxin testing of rAAV vectors can be performed upon request.

The RNA Therapeutics Core (RTC) at the Gene and Cell Therapy Institute of MGB is dedicated to supplying high quality custom circular RNA to the MGB research community and beyond. In addition to providing stock circRNA encoding commonly used proteins for any application, the RTC takes custom synthesis requests to generate circRNA encoding nearly any gene of interest and can formulate RNA into lipid nanoparticles. The RTC plans to offer GMP-grade material at scales required for first in human clinical trials to facilitate the translation of discoveries from bench to bedside. With a suite of cutting-edge RNA technology solutions including machine learning-guided sequence design, the RNA Therapeutics Core stands ready to partner for circRNA research and development.