The Biostatistics Core provides support to investigators in the design and analysis of research studies. This includes assistance with statistical considerations for grant proposals and study protocols and services such as data analysis, database support, data and safety monitoring for clinical trials, statistical programming, and manuscript preparation. The Biostatistics Core is embedded within the MGH Biostatistics group with staff including biostatisticians, statistical programmers, database developers, and project managers.
The goal of the core is to serve the computing needs of the epidemiology community of the Channing Laboratory and beyond. In that vein, the Core provides fast access to our server for data management and analysis and storage for large data sets especially for whole genome genetic studies.
The EMNet HSR Core provides researchers with access to emergency department (ED)-related HSR data, data analysis expertise, and ED survey capabilities to facilitate research on access to emergency care, quality of emergency care, and patient outcomes.
The core maintains 60+ gnotobiotic/germ free isolators for housing of mice under germfree conditions, and biohazard levels 1 and 2 for specifically-associated mice. In-house bred germfree mice are also available to investigators for experiments. In addition the core maintains a 700-cage containment system for idefinite housing of BL1 or BL2 conventional mice with complex flora, and short term gnotobiotic or defined-colonization experiments.
Microbiologically, the core maintains an extensive repository of human and animal commensal isolates and BL-2 pathogens for use in specific-associations as well as for in vitro studies. Experienced microbiologists routinely cultures primary samples from humans and/or animals to study complex samples using culture and/or sequencing-based methods. Aerobic and anaerobic incubators are available to culture bacterial species. As well as short-chain fatty acids (SCFA) analyses.
Molecular support includes DNA extraction, PCR, qPCR, next-generation sequencing-based methods for 16S rRNA gene phylotyping and bacterial genome sequencing.
Bioinformatic analyses/support is available for the samples processed at the MHMC.
The core provides information management and analysis needs of the MGH/Partners/Harvard research community as well as non-profit organizations and industry.
Center for Integrated Healthcare Data Research
The Integrated Analytics core has been established by the division of Pharmacoepidemiology and Pharmacoeconomics to allocate computer programmer effort and closely related costs to federal and non-federal projects. The division of Pharmacoepidemiology and Pharmacoeconomics specializes in analyzing massive data sets related to prescription data use.
