Research Cores

Not a Core. Canary is a free / open-source platform for development of natural language processing (NLP) tools. It is a GUI-based software that is oriented towards researchers, clinicians and analysts without computer science background to empower them to create their own NLP tools.

Provides access to over 3 million IRB approved frozen biosamples from Nurses Health studyI and II, Physicians Health Study I, Healthcare Professionals Follow-up Study and Growing-Up Today Study.

The Digital Research Computing Core provides consulting and technology services to researchers and their project teams at competitive hourly rates. The Core collaborates with users on finding efficient solutions using technology for the unique needs of research environments

The Gene Editing Core (GEC) at the Gene and Cell Therapy Institute (GCTI) provides integrated, high-precision genome engineering services to accelerate the development of gene and cell therapy platforms. With a focus on scalability, scientific rigor, and translational impact, GEC offers advanced editing technologies, high-throughput functional screening, and comprehensive support for both research and therapeutic development. Our end-to-end workflow includes genomic modification, off-target analysis, iPSC reprogramming, lentiviral vector production, and CRISPR-based perturbation screening all backed by validated protocols and stringent quality control.

The Core provides site-related services for multi-site research under the oversight of the Mass General Brigham IRB.

The RNA Therapeutics Core (RTC) at the Gene and Cell Therapy Institute of MGB is dedicated to supplying high quality custom circular RNA to the MGB research community and beyond. In addition to providing stock circRNA encoding commonly used proteins for any application, the RTC takes custom synthesis requests to generate circRNA encoding nearly any gene of interest and can formulate RNA into lipid nanoparticles. The RTC plans to offer GMP-grade material at scales required for first in human clinical trials to facilitate the translation of discoveries from bench to bedside. With a suite of cutting-edge RNA technology solutions including machine learning-guided sequence design, the RNA Therapeutics Core stands ready to partner for circRNA research and development.