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The core offers three lines of service to investigators (a) DNA sequencing (b) DNA synthesis and (c) automation of various assays for research purposes.
The core provides DNA extraction from samples provided by the investigators primarily to Heart Center investigators for a low cost fee. However, the core has the capacity to offer services to other investigators, if requested.
The core offers conventional karyotyping and fluorescent in situ hybridization of both human and rodent samples and array based comparative genome hybridization.
The Coreξprovides flexible, high-quality, high-throughput single nucleotide polymorphisms (SNP) genotyping to the research community. Its mission is to provide services to researchers conducting molecular analyses of germline and somatic DNA collected as part of a wide range of investigations into the molecular epidemiology of cancer, including Genome Wide Association Studies (GWAS).
This core provides access to cutting edge genomics technologies and computational biology resources for Partners investigators.
The core offers Comprehensive Laboratory Animal Monitoring System (CLAMS) studies to noninvasively measure a variety of calorimetric and metabolic data in mice. The calorimetric data recorded by the system includes oxygen consumption and carbon dioxide production values, from which both heat values and respiratory exchange ratios (RER) can be calculated.
The core provides the necessary expertise and services to analyze variations in individual genome that translates into medical decisions, practices, interventions tailored to the individual patient (or a small cohort) based on their predicted response or risk of disease.
The PNGU Core lab provides a variety of services intended to facilitate the identification and characterization of the genetic basis of psychiatric, behavioral, and neurodevelopment disorders as well as other complex disorders.
The core houses an Agilent Seahorse XFe24 instrument and provides functional metabolic studies on live tissues and cells.
The aims to establish the impact of genetic variation on the function of the human body. It is also a resource that provides a source of fresh and stored biological samples from healthy human subjects, as well as an electronic atlas that references the expression of genes to the variation found within those genes for research use.