The core generates clinically approved compounds for PET scans, research tracers for human use, preclinical tracers, novel tracers as requested by investigators and offer small animal imaging services such as microPET/CT and microSPECT.
The core provides high quality, reproducible measures of bone mineral density (BMD) and body composition by dual energy x-ray absorptiometry (DXA).
The program offers high resolutions magnetic resonance (MR), positron emission tomography (PET-CT), signal photon emission computed tomography (SPECT-CT), computed tomography (CT), Fluorescence mediated tomography (FMT-CT/MRI), bioluminescence (BLI), various fluorescence imaging technologies and intravital confocal and multiphoton microscopy. The integrated program also provides several mouse holding facilities for serial surgery anesthesia, veterinary care and injection of imaging agents. Imaging recontruction, 3D display fusion, quantitative imaging analysis and server access area also available.
The core laboratory provides objective anatomic and functional imaging measurements, which enhances the efficiency and quality of clinical trials.
The core offers high-resolution, low dose in vivo imaging of bone structure at the peripheral skeleton in human subjects. Images are acquired in ~ 3 min using a second generation high resolution peripheral computerized tomography (HR-pQCT; XtremeCTII; Scanco Medical AG, Brutisellen, Switzerland). This technology is especially useful in studies of skeletal fragility (e.g., osteoporosis, spinal cord injury).
MIC offers the research community a wide range of magnetic resonance and near infrared imaging services including all types of major structural, functional, neurochemical and electrophysiological techniques to integrate with other research and clinical programs both at McLean Hospital and with research groups in the Boston area. Services include consultation, protocol development, data storage and analysis.
The Musculoskeletal Imaging Research Core (MIRC) offers specialized imaging techniques including quantitative computed tomography (QCT),magnetic resonance (MR) spectroscopy of muscle and high-resolution soft tissue MR imaging.
Offers comprehensive positron emission tomography (PET) services. The core has state of the art facility for PET/CT scans including automated radiochemical synthesis facility, large bore PET scanner, Siemens SPECT system and planar gamma cameras, neuro PET/CT high sensitivity brain scanner, and VISTA small animal micro PET/CT scanner.
The core offers a library of services to study protein-protein interaction at the cellular and molecular level. The technology offered include fluorescence lifetime imaging microscopy (FLIM), Forster resonance energy transfer (FRET) studies, high quality epifluorescence, time lapse microscopy, data analysis and storage facilities.
Provides imaging service for research purposes.