Offers support for apheresis collection services.
The core generates clinically approved compounds for PET scans, research tracers for human use, preclinical tracers, novel tracers as requested by investigators and offer small animal imaging services such as microPET/CT and microSPECT.
The core provides high quality, reproducible measures of bone mineral density (BMD) and body composition by dual energy x-ray absorptiometry (DXA).
The facility is equipped with, Olympus FV1200 confocal microscope (without multi-photon capability) consisting of an Argon 458/477/488/514 nm laser, a Green HeNE 543 nm, a Red HeNe 633 nm laser, and a Coherent ULTRA near infrared tunable Titanium Sapphire laser (690 - 1040 nm). The systems allow a range of experiments with fixed or live samples with time lapse function available on all systems making it possible to perform experiments over time courses in 5 different channels. Investigators with expertise in mammalian cells, yeast cells, Drosophila and Zebra fish embryos and ovaries, bacteria, and other tissues are available to help the users.
Provides small animal husbandry and help with procedures.
The Center for Advanced Molecular Diagnostics (CAMD) is a CLIA-certified Clinical Molecular Diagnostics Laboratory. Our mission is to provide high quality innovative molecular genetic diagnostic services to support the patient care missions of clinicians and clinical researchers.
The Cardiovascular Physiology Core provides cutting edge preclinical research tools including surgery, non invasive rodent and fish imaging and multiplexed ex vivo and in vivo physiologic measurements, including blood pressure. It is a full service preclinical core serving the Partners research community, and its academic and industrial partners.
This Core provides flow cytometry cell sorting services and droplet-based single cell multiomics.
This core provides research investigators with experienced research staff to assist in the start-up, implementation, and close out of clinical research studies. Services provided include Biostatistics, Nursing and Nutrition, Outpatient services and Research coordination.
The goal of the core is to serve the computing needs of the epidemiology community of the Channing Laboratory and beyond. In that vein, the Core provides fast access to our server for data management and analysis and storage for large data sets especially for whole genome genetic studies.
The Chronobiology Core provides a central resource for trained personnel specialized in Chronobiology procedures, available to investigators on an hourly basis. The core simplifies new-study start-ups, reduces costs by sharing personnel among studies, provides a centralized pool of similarly trained personnel, provides specialized training in chronobiology procedures for investigators' personnel, and can assist investigators in implementing new study procedures and equipment.
The Circulating Tumor Cell (CTC) core provides users with FDA-approved method for the isolation and quantitation of circulating tumor cells from peripheral blood samples of patients with metastatic cancers.
The facility is equipped with, Nikon TE200-U inverted microscope with Nomarski optics, epifluorescence and scanning confocal system. A range of experiments with fixed or live samples with time lapse function and fluoresecence recovery after photobleaching (FRAP) are available.
Provides clinical samples or consented patient samples to research purposes.
Our core mission is to advance health services and outcomes research that improves the quality, safety, value, and equity of surgical care. To support this mission, we will develop, securely manage, and steward robust data resources that enable high-quality research and collaboration across Mass General Brigham. The core will provide expert biostatistical and methodological consultation to CSPH investigators and surgeon scientists, supporting study design, data acquisition and management, advanced quantitative and qualitative analyses, and interpretation of findings. In addition, we will facilitate access to institutional data sources, ensure appropriate data governance and security, and partner with investigators to translate research findings into impactful publications, grants, and innovations that advance surgical care delivery.
The mission of the Cardiovascular, Diabetes, and Metabolic Disorders (CVDM) Research Center is to foster and stimulate collaborative research and technological innovation that will lead to groundbreaking and effective approaches for the diagnosis, prevention and treatment of cardiovascular diseases, diabetes, and obesity. The core is a repository of human myocardial, vascular, and stromal tissues.
The BWH Emergency Medicine Research Core provides research investigators with assistance in the implementation of clinical research studies, especially in the emergency department. This includes general research coordination (screening, consenting, performing study procedures, data entry), project management (IRB and regulatory documents maintenance), basic data service (REDCap development and maintenance, data entry). We can also provide Qualified Bilingual research staff who can interact with Spanish-speaking research participants).
The HSDRC provides access to fresh and banked human skin specimens and cutting edge techniques for analysis of human skin including CyTOF mass cytometry, multiplex immunofluorescence microscopy, T cell receptor sequencing, and NanoString gene expression analysis.
The ID Retrovirology Core processes samples from HIV- and HCV-infected patients participating in clinical research studies. Services include plasma and serum separation, peripheral blood Cncermononuclear cell isolation and cryopreservation, and preparation of cell pellets.
Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis in adults and children.
This research resource core will organize, label, maintain, and distribute rare-earth metal labeled antibodies for CyTOF mass cytometry.
The mission of the Mass General Brigham Research Assay Core Laboratory is to provide a comprehensive menu of state-of-the-art high-quality research assays to the Partners and non-Partners research communities at competitive costs. The BRAC Laboratory is a dynamic entity seeking to meet the needs of its investigators with new and relevant technologies, and evolving research support. We are CLIA certified and accredited by the Joint Commission.
The core maintains 60+ gnotobiotic/germ free isolators for housing of mice under germfree conditions, and biohazard levels 1 and 2 for specifically-associated mice. In-house bred germfree mice are also available to investigators for experiments. In addition the core maintains a 700-cage containment system for idefinite housing of BL1 or BL2 conventional mice with complex flora, and short term gnotobiotic or defined-colonization experiments. Microbiologically, the core maintains an extensive repository of human and animal commensal isolates and BL-2 pathogens for use in specific-associations as well as for in vitro studies. Experienced microbiologists routinely cultures primary samples from humans and/or animals to study complex samples using culture and/or sequencing-based methods. Aerobic and anaerobic incubators are available to culture bacterial species. As well as short-chain fatty acids (SCFA) analyses. Molecular support includes DNA extraction, PCR, qPCR, next-generation sequencing-based methods for 16S rRNA gene phylotyping and bacterial genome sequencing. Bioinformatic analyses/support is available for the samples processed at the MHMC.
The core maintains 60+ gnotobiotic/germ free isolators for housing of mice under germfree conditions, and biohazard levels 1 and 2 for specifically-associated mice. In-house bred germfree mice are also available to investigators for experiments. In addition the core maintains a 700-cage containment system for idefinite housing of BL1 or BL2 conventional mice with complex flora, and short term gnotobiotic or defined-colonization experiments.
Microbiologically, the core maintains an extensive repository of human and animal commensal isolates and BL-2 pathogens for use in specific-associations as well as for in vitro studies. Experienced microbiologists routinely cultures primary samples from humans and/or animals to study complex samples using culture and/or sequencing-based methods. Aerobic and anaerobic incubators are available to culture bacterial species. As well as short-chain fatty acids (SCFA) analyses.
Molecular support includes DNA extraction, PCR, qPCR, next-generation sequencing-based methods for 16S rRNA gene phylotyping and bacterial genome sequencing.
Bioinformatic analyses/support is available for the samples processed at the MHMC.
The core provides the necessary expertise and services to analyze variations in individual genome that translates into medical decisions, practices, interventions tailored to the individual patient (or a small cohort) based on their predicted response or risk of disease.
The BWH NeuroTechnology Studio provides access to advanced instrumentation for optical microscopy, genomics, metabolic imaging and other technologies, including image analysis software. We also provide expert support and training for new and experienced users. Our primary focus is neuroscience research but we also welcome users from other fields.
Our specialized research nursing core supports neonatal studies across the care continuum. In the NICU, research nurses approach parents, educate clinical staff, coordinate studies, and perform study procedures when applicable. In the postpartum unit, they engage families of well newborns, introduce eligible studies, answer questions, and connect interested parents with study teams.
Center for Integrated Healthcare Data Research
The Integrated Analytics core has been established by the division of Pharmacoepidemiology and Pharmacoeconomics to allocate computer programmer effort and closely related costs to federal and non-federal projects. The division of Pharmacoepidemiology and Pharmacoeconomics specializes in analyzing massive data sets related to prescription data use.
Provides imaging service for research purposes.
The core houses an Agilent Seahorse XFe24 instrument and provides functional metabolic studies on live tissues and cells.
The Sleep & EEG Core within the Division of Sleep Medicine (DSM) provides an integrated infrastructure and knowledge base in support of research projects that use polysomnography (PSG), quantitative EEG analysis and related methodologies
The Core provides cell sorting and flow cytometry analysis services to the research community at the Brigham and Women's Hospital (BWH) and the Longwood Medical area.
Centralized repository of patient and normal tissue and blood samples.
The Brigham and Women’s Hospital Translational Discovery Laboratory (formerly The Invasive Cardiovascular Experimental Laboratory) is a large animal translational research facility that focuses on developing novel therapies for human disease. The Translational Discovery Laboratory team works closely with investigators to design experiments, perform procedures, collect data, and harvest tissue. Services include consultation on experimental design, protocol submission, and direct management of procedures. The facility also functions as a physician training venue for novel medical devices.
