The AUTISM RESEARCH CORE (ARC) at the Lurie Center in Lexington, MA provides a suite of services including neuropsychological assessment and testing, clinical research study implementation, including recruitment and regulatory management, nursing services, phlebotomy and sample processing, and consulting services.
The BioMEMS Core (BMC) provides know-how and state-of-the-art facilities for biomedical investigators interested in new microfluidic tools to measure, control, and perturb the cellular microenvironment at the scale comparable to cell size.
The Biostatistics Core provides support to investigators in the design and analysis of research studies. This includes assistance with statistical considerations for grant proposals and study protocols and services such as data analysis, database support, data and safety monitoring for clinical trials, statistical programming, and manuscript preparation. The Biostatistics Core is embedded within the MGH Biostatistics group with staff including biostatisticians, statistical programmers, database developers, and project managers.
Bone Cells Core facility provides specific-type bone cells isolated directly from wild type and/or genetically modified animals. The core provides tools, such as vectors, plasmid and lentiviruses, to manipulate these cells. Finally, the Core offers in vitro fluid flow and simulated microgravity experiment services.
offers access to Nikon A1 laser scanning confocal microscope with state of the art imaging facility with resonant scanning and spectral imaging capabilities.
Cores Listing Description
The Core provides various DNA sequencing services; utilizing Illumina short-read, Oxford Nanopore long-read, and Sanger sequencing. The Core also provides mouse genotyping, plasmid DNA preparation, PCR purification, fragment analysis, and custom automation services.
The Cell Resource Core specializes in liver cell isolation's from human, rat and mouse tissues. We have also expanded our services to include small animal microsurgery, organ perfusion, micro-surgical tool rentals and training in all of the above services.
Provides small animal husbandry and help with procedures.
We are the research arm of the Center for Integrated Diagnostics (CID) at MGH. We help with early translation all the way to clinical validation, integration and utility assessment in practice. Established in 2007 as the Translational Research Lab in conjunction with the MGH Cancer Center, we developed cutting edge molecular testing panels via NGS. We now support many clinical trials, assess and develop diagnostics, execute novel research, provide orthogonal testing, assay development, data services, and evaluate promising new technology.
The Core will provide services to measure levels of a variety of signaling molecules, such as cAMP, IP3, iCa++, and P-ERK-1/2, in cell culture or tissue systems.
The Clinical Research Center provides Nursing, Metabolism and Nutrition, and Lab support services to the MGH and affiliated communities. Our clinical unit is capable of supporting a wide variety of both inpatient and outpatient research studies, as well as ancillary lab assay support.
Scheduling and access to Leica SP8 and Leica SPE confocal microscopes
The core offers:
*The Olympus Multiphoton FVMPRE-RS Microscopy System for cutting-edge research imaging
The program offers high resolutions magnetic resonance (MR), positron emission tomography (PET-CT), signal photon emission computed tomography (SPECT-CT), computed tomography (CT), Fluorescence mediated tomography (FMT-CT/MRI), bioluminescence (BLI), various fluorescence imaging technologies and intravital confocal and multiphoton microscopy. The integrated program also provides several mouse holding facilities for serial surgery anesthesia, veterinary care and injection of imaging agents. Imaging recontruction, 3D display fusion, quantitative imaging analysis and server access area also available. In addition the core offers histology.
The DF/HCC Specialized Histopathology Services Core in MGH provides high-quality, timely, state-of-the-art technical and professional pathology services to investigators. The core has expertise working with human tissues as well as a variety of experimental models (including rodents, fish, pigs and monkeys). The Core performs routine histology and special histochemical stains and also assists in experimental design and the development, application, and interpretation of biomarkers.
Services include:
• Tissue trimming, processing and embedding,
• Cutting and staining of paraffin-embedded sections
• Cutting and staining of frozen OCT sections
• Special stains
• Immunohistochemistry manual - optimization and staining, for routine and novel markers
• Immunohistochemistry automated - optimization and staining, for routine and novel markers
• Eye pathology services (human and mouse)
• Dual staining (immunohistochemistry)
The core laboratory provides objective anatomic and functional imaging measurements, which enhances the efficiency and quality of clinical trials.
The mission of the Clinical Research Program Study Coordinators Core (CRP SCC) is to provide infrastructure support for clinical research investigators at the MGH.
The EMNet HSR Core provides researchers with access to emergency department (ED)-related HSR data, data analysis expertise, and ED survey capabilities to facilitate research on access to emergency care, quality of emergency care, and patient outcomes.
This core provides frozen fecal material for transplantation for treatment of recurrent colitis, especially C. difficile colitis.
This core provides access to cutting edge genomics technologies and computational biology resources for MGB investigators.
The core offers high-resolution, low dose in vivo imaging of bone structure at the peripheral skeleton in human subjects. Images are acquired in ~ 3 min using a second generation high resolution peripheral computerized tomography (HR-pQCT; XtremeCTII; Scanco Medical AG, Brutisellen, Switzerland). This technology is especially useful in studies of skeletal fragility (e.g., osteoporosis, spinal cord injury).
The core offers histopathological studies including examination of tumor specimen, neurohistopathology, immunohistochemical studies on human, non-human primate and rodents calibrated primarily for MGH users. A sister facility caters BWH users.
The Core provides an advanced level of sorting and analysis services to its investigators.
This core investigates HIV pathogenesis and evaluates preventive and therapeutic interventions, as well as immuno-oncological frameworks. This endeavor is done by the creation of an improved humanized mouse model capable of generating HIV-specific human cellular and humoral immune responses.
The Imaging Core provides services for image capture, image computation, and biomarker staining.
The MGH Metabolic Imaging Core (MMIC) provides advanced human metabolic and body‑composition imaging services, including high‑resolution Magnetic Resonance Imaging (MRI), MR spectroscopy (MRS), quantitative CT (QCT), and ultrasound, along with specialized software and AI‑driven tools for quantitative image analysis. The Core is staffed by a multidisciplinary team with deep expertise in radiology, MR spectroscopy, and biomedical engineering, offering comprehensive support from protocol development through image acquisition, QA/QC, and data interpretation. MMIC maintains rigorous standardized procedures to ensure high‑quality, reproducible research and collaborates widely to harmonize imaging methodologies and advance analytic tools.
The Laboratory for Molecular Medicine (LMM) is a CLIA-certified molecular diagnostic laboratory, operated by Partners HealthCare Personalized Medicine.Ê
The core provides information management and analysis needs of the MGH/Partners/Harvard research community as well as non-profit organizations and industry.
The MGH CNY Zebrafish Cooperative is ~ a 3000 sq. ft. Aquatics facility located on the 4th floor of Building 149 in the Charlestown Navy Yard. With more than 5000 tanks, the goal of the Cooperative is to provide access and a cost sharing plan to distribute the aquatics facility overhead expenses. Investigators are charged a “per rack” rate based on monthly use. Facility charges reflect costs associated with routine maintenance, replacement costs for broken equipment, brine shrimp and rotifers, and salary support for facility staff. The rate for Low Density (LD) racks is proportional to charges of High Density (HD) racks that have 25% greater capacity. Common nursery space is shared among all investigators and is not subject to per rack charges. The core intends to run revenue neutral and adjust its yearly budgets when expenses run above or below the projected budget. Core use and membership requires approval by the Scientific Advisory Committee of the Cooperative.
This core provides flexible morphometric measurement service, especially neuroanatomic morphometry, to meet the needs of the clinical community. It operates in conjunction with Martinos center for Imaging.
The mission is collect and bank biological samples from normal individuals and patients for studies by Partners Investigators.
The Core provides access to the most sophisticated flow cytometers and mass cytometer (Helios) presently available for cell sorting, flow cytometric analysis and single-cell mass cytometric analysis respectively.
Offers comprehensive positron emission tomography (PET) services. The core has state of the art facility for PET/CT scans including automated radiochemical synthesis facility, large bore PET scanner, Siemens SPECT system and planar gamma cameras, neuro PET/CT high sensitivity brain scanner, and VISTA small animal micro PET/CT scanner.
The MDSC in the Center for Genomic Medicine provides custom services to enable genetic studies in human disease, including processing of blood and skin samples to establish cell lines, DNA and RNA extraction, genotyping and sequencing, and access to Clinical Genetic Research Facility space for subject contact/phenotyping.
The core offers a library of services to study protein-protein interaction at the cellular and molecular level. The technology offered include fluorescence lifetime imaging microscopy (FLIM), Forster resonance energy transfer (FRET) studies, high quality epifluorescence, time lapse microscopy, data analysis and storage facilities.
The core offers synthesis and purification of custom peptides. It also offers protein sequencing (automated Edman degradation) and protein mass spectrometry services.
The core offers access to state-of-the-art optical, fluorescence, and electron microscopy (including immunogold labeling), and image analysis software. Major equipment includes a JEOL 1011 electron microscope, Nikon A1R, Nikon AXR and Zeiss LSM800 with Airyscan confocal microscope platforms, Nikon 90i and 80i conventional fluorescence microscopes, Microtome, Vibratome,Leica cryostats and ultramicrotomes, and an MMI laser cut micro dissection system.
Supports BSL-3 level experimental procedures by investigators at Partners Healthcare and Boston community. The core aims to enable external users to access the unique benefits of a BSL-3 facility, and to provide comprehensive services in support of this goal.
The Ragon Institute offers flow cytometry, fluorescence-activated cell sorting, and imaging cytometry services and equipment access.
The Ragon Institute Microscopy core provides access to microscopes and analysis workstations. Our equipment includes a Zeiss CD7 Cell Discoverer, a TissueFAXS SQL slide scanner for confocal imaging, and a TissueFAXS scanner for brightfield and fluorescence.
Our objective is to provide software application development and hosting services. We would like to utilize our expertise and software modules already created to help others to organize, store, analyze and share scientific data.
The Sample Processing Laboratory (SPL) understands that the biological integrity of a sample is the foundation of every breakthrough. We utilize validated and customizable workflows to isolate, stabilize, and preserve a diverse array of biospecimens, ensuring they are optimized for downstream analysis, long-term storage, or domestic/international shipments.
The Smart and Autonomous Medical Systems (SaAMS) Core provides access to diverse medical devices, mechanical and electronic patient simulators, medical gas supplies, measurement instrumentation, data acquisition and storage, and access to the experts who know them best.
The Translation Research Center provides support for industry-sponsored clinical trials for MGH investigators. Our clinical unit is capable of supporting a wide variety of both inpatient and outpatient research studies, as well as providing project management, regulatory, and research coordinator support.
