The Advanced Tissue Resource Center in the Department of Neurology at Massachusetts General Hospital serves as a molecular and anatomic neuropathology resource for the Boston neuroscience community. Our services incorporate advanced micro-molecular profiling technologies into studies of human neurodegenerative and psychiatric diseases.
Array Tomography is a light microscopic method of analysis that allows increased structural detail to be achieved at the light microscope level such as that associated with individual synapses.
The Core will provide statistical services that include consultation for grant preparation, data management, data analysis, electronic data capture, and the management and coordination of multi-center clinical trials to Clinical and Laboratory Investigators.
Bone Cells Core facility provides specific-type bone cells isolated directly from wild type and/or genetically modified animals. The core provides tools, such as vectors, plasmid and lentiviruses, to manipulate these cells. Finally, the Core offers in vitro fluid flow and simulated microgravity experiment services.
offers access to Nikon A1 laser scanning confocal microscope with state of the art imaging facility with resonant scanning and spectral imaging capabilities.
The core offers three lines of service to investigators (a) DNA sequencing (b) DNA synthesis and (c) automation of various assays for research purposes.
This core is a resource center that optimizes and utilizes all donor organs to provide cells, tissues and organs for research and therapeutic uses.
Provides small animal husbandry and help with procedures.
The Core will provide services to measure levels of a variety of signaling molecules, such as cAMP, IP3, iCa++, and P-ERK-1/2, in cell culture or tissue systems.
provides access to Nikon A1 automated high speed image capturing microscope.
The core offers: *The Olympus Multiphoton FVMPRE-RS Microscopy System for cutting-edge research imaging *The Leica SP8 Laser Scanning Microscope *The Nikon
The program offers high resolutions magnetic resonance (MR), positron emission tomography (PET-CT), signal photon emission computed tomography (SPECT-CT), computed tomography (CT), Fluorescence mediated tomography (FMT-CT/MRI), bioluminescence (BLI), various fluorescence imaging technologies and intravital confocal and multiphoton microscopy. The integrated program also provides several mouse holding facilities for serial surgery anesthesia, veterinary care and injection of imaging agents. Imaging recontruction, 3D display fusion, quantitative imaging analysis and server access area also available.
The core provides DNA extraction from samples provided by the investigators primarily to Heart Center investigators for a low cost fee. However, the core has the capacity to offer services to other investigators, if requested.
The core provides investigators with the necessary expertise and resources to design and undertake pharmacokinetic studies in the context of phase I and phase II clinical trials, and preclinical investigations.
The core laboratory provides objective anatomic and functional imaging measurements, which enhances the efficiency and quality of clinical trials.
The mission of the Clinical Research Program Study Coordinators Core (CRP SCC) is to provide infrastructure support for clinical research investigators at the MGH.
This core provides frozen fecal material for transplantation for treatment of recurrent colitis, especially C. difficile colitis.
This core provides access to cutting edge genomics technologies and computational biology resources for Partners investigators.
The core offers the services of one of only 4 Xtreme CT scanners currently in the US. High resolution peripheral computerized tomography (HR-pQCT; Xtreme CT; Scanco Medical AG, Bassendorf, Switzerland) is a new technology that allows for 3 dimensional reconstruction of bone microarchitecture and image separation of cortical and trabecular bone. This technology is especially useful in women's health studies.
The core offers histopathological studies including examination of tumor specimen, neurohistopathology, immunohistochemical studies on human, non-human primate and rodents calibrated primarily for MGH users. A sister facility caters BWH users.
The Core provides an advanced level of sorting and analysis services to its investigators.
This core investigates HIV pathogenesis and evaluates preventive and therapeutic interventions, as well as immuno-oncological frameworks. This endeavor is done by the creation of an improved humanized mouse model capable of generating HIV-specific human cellular and humoral immune responses.
The Core isolates and distributes high quality human, non-human primate, porcine and rodent islets for basic scientific research studies.
The Musculoskeletal Imaging Research Core (MIRC) offers specialized imaging techniques including quantitative computed tomography (QCT),magnetic resonance (MR) spectroscopy of muscle and high-resolution soft tissue MR imaging.
The core provides information management and analysis needs of the MGH/Partners/Harvard research community as well as non-profit organizations and industry.
The core has a Zeiss LSM710 Inverted Confocal Microscope with floating air table, and CO2 and a heated stage insert for live-cell imaging
The DF/HCC Specialized Histopathology Services Core in MGH provides high-quality, timely, state-of-the-art technical and professional pathology services to investigators. The core has expertise working with human tissues as well as a variety of experimental models (including rodents, fish, pigs and monkeys). The Core performs routine histology and special histochemical stains and also assists in experimental design and the development, application, and interpretation of biomarkers. Services include: • Tissue trimming, processing and embedding, • Cutting and staining of paraffin-embedded sections • Cutting and staining of frozen OCT sections • Special stains • Immunohistochemistry manual - optimization and staining, for routine and novel markers • Immunohistochemistry automated - optimization and staining, for routine and novel markers • Eye pathology services (human and mouse) • Dual staining (immunohistochemistry)
Offers comprehensive positron emission tomography (PET) services. The core has state of the art facility for PET/CT scans including automated radiochemical synthesis facility, large bore PET scanner, Siemens SPECT system and planar gamma cameras, neuro PET/CT high sensitivity brain scanner, and VISTA small animal micro PET/CT scanner.
This core provides flexible morphometric measurement service, especially neuroanatomic morphometry, to meet the needs of the clinical community. It operates in conjunction with Martinos center for Imaging.
The Core provides access to the most sophisticated flow cytometers and mass cytometer (Helios) presently available for cell sorting, flow cytometric analysis and single-cell mass cytometric analysis respectively.
The core offers a library of services to study protein-protein interaction at the cellular and molecular level. The technology offered include fluorescence lifetime imaging microscopy (FLIM), Forster resonance energy transfer (FRET) studies, high quality epifluorescence, time lapse microscopy, data analysis and storage facilities.
This core custom generates cDNA clones and shRNA lentiviral constructs for investigators.
The Laboratory for Molecular Medicine (LMM) is a CLIA-certified molecular diagnostic laboratory, operated by Partners HealthCare Personalized Medicine.Ê
The core offers synthesis and purification of custom peptides. It also offers protein sequencing (automated Edman degradation) and protein mass spectrometry services.
The core offers access to state of the art optical, fluorescence and electron microscopy (including immunogold labeling), and image analysis software. Major equipment includes a JEOL 1011 electron microscope, Nikon A1R and Zeiss LSM800 with Airyscan confocal microscope platforms, Nikon 90i and 80i conventional fluorescence microscopes, Leica cryostats and ultramicrotomes, and an MMI laser cut micro dissection system.
Supports BSL-3 level experimental procedures by investigators at Partners Healthcare and Boston community. The core aims to enable external users to access the unique benefits of a BSL-3 facility, and to provide comprehensive services in support of this goal.
The Ragon Institute offers flow cytometry, fluorescence-activated cell sorting, and advanced microscopy and image analysis services.
The Sample Processing Laboratory (SPL) is a centralized core facility for processing research samples obtained from patients enrolled in clinical trials of anticancer chemotherapeutic agents at the MGH Cancer Center (MGHCC), for short-term storage and shipment to designated laboratories.
The core will offer advice on strategies for cloning, provide relevant plasmids and help packaging lentivirus based vectors, retrovirus and Aden associated virus (AAV). Custom packaging and tittering services are also offered.